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br Materials and methods br Results br
2020-04-09

Materials and methods Results Discussion In rodent species, CYP2E1 and CYP2B have been implicated in CCl4 metabolism. In this study, we used expressed human CYP2E1 to show that this enzyme is a high-affinity catalyst responsible for low-dose CCl4 metabolism. Studies employing an inhibitory
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Compression The L vertebral body was tested
2020-04-09

Compression: The L4 vertebral body was tested in compression with loads applied along the craniocaudal axis using an Instron 8800 device at a rate of 3mm/min. Load displacement data were captured using Bluehill software. The ultimate load, yield load, stiffness, ultimate stress, yield stress and You
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All tested antibodies exhibited positive immunoreactivity in
2020-04-09

All tested bms-690514 exhibited positive immunoreactivity in NSCLC tumors, with N’-epitope being the less expressed (both as overall positivity and number of positive cases, or intensity combined with number of positive cells, as provided by H-Score. This result is in accordance with previous studi
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The ADME profile of AAT was very promising
2020-04-09

The ADME profile of AAT-008 () was very promising, with high stability in HLM. The pre-clinical pharmacokinetic properties of AAT-008 were also assessed in rats (Sprague-Dawley, male), dogs (beagle, male), and monkeys (cynomolgus, male). The experimentally determined parameters are summarized in . A
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br Results br Discussion The importance of
2020-04-08

Results Discussion The importance of mitochondria for the initiation and progression of tumorigenesis is now emerging. It is evident that, despite the well-known Warburg effect, tumors have active mitochondrial bioenergetic metabolism (Marin-Valencia et al., 2012, Hensley et al., 2016). Disrup
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Assessment of the activity of native
2020-04-08

Assessment of the activity of native and denatured TAT-CPG2 after penetration suggests that TAT-CPG2 has been successfully delivered into the cells, and the transduced enzyme is functional inside the cells. The enzyme activity of both native and denatured TAT-fusion proteins in the cultured HepG2 sn
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Ageing is associated with increased reactive oxygen species
2020-04-07

Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati
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A key inciting event in
2020-04-07

A key inciting event in atherosclerosis is the deposition of circulating low-density lipoprotein (LDL) in the subendothelial space of major arteries. In the subendothelium, native LDL is no longer protected by circulating antioxidants and is oxidatively modified to oxidized LDL (OxLDL) [5]. OxLDL is
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In contrast irinotecan has shown much less myelosuppression
2020-04-07

In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,
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br Results and discussion A systematic search for genes enco
2020-04-07

Results and discussion A systematic search for genes encoding H+-PPases was carried out by PCR using genomic DNA from a wide range of protozoa as templates and degenerate oligonucleotides, designed from amino Mifepristone australia domains conserved in H+-PPases of higher plants and the proteoba
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With the narrow SAR of the tail
2020-04-07

With the narrow SAR of the tail favouring the ortho sulfone group, we examined the remaining position open to substitution at the pyrazole 3-position, in an attempt to at least moderate the excessive human PPB (). Lipophilic groups in this position maintained huge shifts in potency in the absence or
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6,7-dihydroxy Bergamottin Characterization factor is another
2020-04-07

Characterization factor is another variable suggested in the presented correlation. Specific gravity (SG) and normal boiling point of hydrocarbons are needed to calculate Watson characterization factor [61], [62]: The boiling point of bitumen cannot be precisely measured, because bitumens contain
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Some natural products such as curcumin resveratrol
2020-04-07

Some natural products, such as curcumin, resveratrol, and sulforaphane, are known to activate Nrf2 in both in vivo and in vitro experimental models where Nrf2-mediated gene Gap19 plays a crucial protective role [8]. Under basal conditions, Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) r
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br Experimental Procedures Further details
2020-04-07

Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific Penciclovir Sodium migrate to the periphery of B cell follicles a
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br Effect of DPP Inhibitors on the Clinical Course of
2020-04-07

Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom
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