• br Methods br Acknowledgements We are grateful to

  2022-06-02

  

  Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo

• Clodronate Disodium br Conclusion and future perspectives In

  2022-06-02

  

  Conclusion and future perspectives In the setting of myocardial I/R stress, HDAC activity is induced and contributes to myocardial injury. HDAC inhibition appears to protect the Clodronate Disodium from I/R injury by activating a variety of pro-survival molecular pathways. From a clinical releva

• corticotropin releasing factor Human immunodeficiency virus

  2022-06-02

  

  Human immunodeficiency virus type 1 (HIV-1) is responsible for the corticotropin releasing factor pandemic; notification is compulsory in Brazilian blood banks since 1988. From 1980 to 2016, the Brazilian MH reported 882,810 HIV/AIDS cases, with 52.3% in the southeast region. HIV/HCV co-infection

• br STAR Methods br Acknowledgments

  2022-06-02

  

  STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a

• In contrast to sGC stimulators

  2022-06-02

  

  In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading

• Furthermore the role of GSK in the pathogenesis of

  2022-06-02

  

  Furthermore, the role of GSK-3 in the pathogenesis of inflammation has been widely documented as it accompanies inflammatory conditions such as diabetes mellitus, mood disorders, Alzheimer’s disease, cancer (Jope et al., 2007), and has been associated with atherothrombotic CVD events. However, anoth

• In addition to vertebrate species GnRH has been identified i

  2022-06-02

  

  In addition to vertebrate species, GnRH has been identified in invertebrates, such as in the Protochordate Ciona intestinalis (Powell et al., 1996; Adams et al., 2003), the decapods mollusk Octopus vulgaris (Iwakoshi et al., 2002), the gastropod mollusk, the sea hare Aplysia californica (Zhang et al

• gamma-Glu-Cys br Acknowledgments The financial support from

  2022-06-01

  

  Acknowledgments The financial support from the National Natural Science Foundation of China (Nos. 31460422 and 31060210), the Natural Science Foundation of Jiangxi Province, China (20171BAB204029 and 20143ACB20006), the Project of Science and Technology of Jiangxi Provincial Education Department,

• br Experimental section br Acknowledgments MIN

  2022-06-01

  

  Experimental section Acknowledgments MIN6 Pyridoxal 5 phosphate were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574

• Cx has been shown to

  2022-06-01

  

  Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa b-raf inhibitors [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the ro

• To investigate the potential molecular mechanism of FXR medi

  2022-06-01

  

  To investigate the potential molecular mechanism of FXR-mediated regulation of liver cancer cell proliferation, gene expression profiles were determined using Agilent arrays in SK-Hep-1-FXR and NC after treatment with the FXR agonist GW4064. The results indicate that mTOR and S6k are involved in div

• Additionally to their peripheral effects evidence indicate a

  2022-06-01

  

  Additionally to their peripheral effects, evidence indicate a role for ETs in the central nervous system (Mosqueda-Garcı́a et al., 1993). Indeed, using Northern blot analysis and in situ hybridization it has been shown the presence of immunoreactive ET of non-vascular origin and of neuronal location

• br Acknowledgments The breast cancer

  2022-06-01

  

  Acknowledgments The breast cancer laboratory is supported by the Australian National Health and Medical Research Council (NHMRC) grants no. 1016701, no. 1024852, no. 1086727; NHMRC IRIISS; the Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium and Op

• Tozasertib LSD also contributes to the regulation

  2022-06-01

  

  LSD1 also contributes to the regulation of specific programs of gene expression in postmitotic, fate-committed neurons. Perhaps its most specialized role is in the complex series of epigenetic regulatory events that permit each olfactory sensory neuron to express one and only one of the thousands of

• GSK503 In this study there is

  2022-06-01

  

  In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual GSK503 emptying was needed until reflex bladder emptying was established (Lu et al., 2008, Ma et al., 2015). Because

15611 records 416/1041 page Previous Next First page 上5页 416417418419420 下5页 Last page