• Imatinib was first approved for the treatment of

  2025-01-21

  

  Imatinib was first approved for the treatment of Philadelphia chromosome positive chronic myelogenous leukemia in 2001 [25]. This first approved small molecule antagonist is quite unusual in that it provides a durable response that lasts for more than a decade in the majority of patients. Imatinib h

• Di ethylhexyl phthalate DEHP is one of the most

  2025-01-21

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After ceftazidime avibactam into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influe

• br Does TIPARP contribute to the diverse species

  2025-01-21

  

  Does TIPARP contribute to the diverse species sensitivity to TCDD toxicity? In chick embryo hepatocytes TIPARP was reported to mediate the TCDD-dependent suppression of hepatic gluconeogenesis, by reducing cellular NAD+ levels and reducing PCK1 expression, suggesting that ADP-ribosylation enhance

• br A Rs which were cloned and then

  2025-01-21

  

  A3Rs, which were cloned and then pharmacologically identified in the early 1990s, are expressed in multiple organs and peripheral tissues including BI6727 involved in inflammatory responses (Gessi et al., 2008, Borea et al., 2014). While low levels are expressed in the CNS, A3R agonists produce fu

• A borderline significant effect of women s age has

  2025-01-21

  

  A borderline significant effect of women's age has been observed for ADA6 only. For ADA2 the proportion of the *1/*1 genotype is 69.4% in women aged ≤36 years vs. 66.9% in women aged ≥36 years (p=0.944). The proportion of ADA6*1 allele carriers is 32.6% in women aged ≤36 years vs. 49. 8 in women age

• MicroRNA miRNA is an abundant

  2025-01-21

  

  MicroRNA (miRNA) is an abundant group of small (22-nucleotide) noncoding RNA molecules that directly binds with 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) to regulate gene expression, playing an important role in variety of biological processes including cell proliferation, apopto

• Patients with AAG often respond

  2025-01-21

  

  Patients with AAG often respond to intravenous immunoglobulin or plasma exchange. If these therapies are inadequate, ongoing immune suppression with steroids, azathioprine, mycophenylate or rituximab have been shown to be effective in case reports. Our patient seemed initially resistant to steroid t

• br In our experience br History of ER and ACh

  2025-01-21

  

  In our experience History of ER and ACh tests As shown in Table 1, Stein et al. first reported the usefulness of intravenous injection of ER in diagnosing coronary insufficiency in 1949 [16]. In 1972, the first ER spasm provocation test was employed at the Cleveland Clinic during cardiac cathe

• In humans the major LOs

  2025-01-21

  

  In humans, the major LOs are subdivided by their positional specificity into 5-(ALOX5), 12-(ALOX12) and 15-LO (ALOX15) (Kuhn et al., 2015). 5-LO is the key enzyme for LT biosynthesis and mainly found in mature cells from myeloid origin, including neutrophil, eosinophil and basophil granulocytes, mon

• It is now well established that the cumulative exposure to

  2025-01-20

  

  It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar

• In the early s in

  2025-01-20

  

  In the early 2000s, in addition to above-mentioned plant derived compounds, several peptide fragments from protein sources (e.g. gelatin, egg yolk, meat, fish, chicken, legumes) have been also confirmed as potential natural antioxidants and extensive studies about bioactive peptides have been conduc

• br Experimental section br Acknowledgements

  2025-01-20

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• Infections inflammation and corneal transplant can all cause

  2025-01-20

  

  Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid plk1 inhibitor into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the cornea.

• T-5224 The specific mechanism and neurotoxic A species are y

  2025-01-20

  

  The specific mechanism and neurotoxic Aβ T-5224 are yet to be elucidated, however recent studies have provided significant evidence for the amyloid channel hypothesis. These reports have established that relatively small oligomers ( Conflict of interest Acknowledgements This work was financed

• br Introduction AMP activated protein kinase AMPK has

  2025-01-20

  

  Introduction AMP-activated protein kinase (AMPK) has been found to be a key character against cardiovascular diseases and cellular stress. When activated by certain stress, AMPK regulates sugars and fatty acids that are good or detrimental to the heart. For example, targeting AMPK phosphorylation

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