• Idelalisib demonstrates a dual mechanism of action

  2019-05-31

  

  Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour cycloastragenol by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the protectiv

• Another mechanism is that J waves represent

  2019-05-31

  

  Another mechanism is that J waves represent a repolarization abnormality where J waves are created by the transmural voltage gradient [16]. During myocardial ischemia, the membrane ionic currents are known to be augmented, in turn augmenting the transient outward current (Ito). Augmented Ito would r

• In addition to CAF in the primary

  2019-05-31

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

• br Discussion We describe an additional diagnosis to conside

  2019-05-31

  

  Discussion We describe an additional diagnosis to consider when BVT is identified. One of the proposed mechanisms of BVT include elevated intracellular calcium, causing delay after depolarization in anatomically separate parts of the conducting system. Baher et al. [1] proposed that two separate

• En la obra de Cuadra una familia campesina confronta

  2019-05-30

  

  En la obra de Cuadra, una familia campesina confronta trágicamente la guerra civil entre conservadores y liberales. Víctimas pasivas de las élites y no actores políticos, estos campesinos ven cómo los principios familiares tradicionales y del minifundio son desarticulados por la guerra y el abuso de

• Percebemos ent o tentando tra ar uma linha que

  2019-05-30

  

  Percebemos, então, tentando traçar uma linha que amarre as discussões dos intelectuais mencionados, que as revoluções cubana e sandinista foram representadas positivamente na revista Araucaria de Chile, através de argumentos relacionados ao desenvolvimento e à popularização da cultura após apexbio d

• Entretanto quando as elei es

  2019-05-30

  

  Entretanto, quando as eleições presidenciais se aproximaram em 1990 o país vivia um momento bastante diferente, marcado não somente pelos agudos problemas econômicos já descritos, mas também pelo incremento da ação militar urbana de Sendero Luminoso, uma vez que make film. partir de 1989 sua lideran

• br La flor de Coleridge En el ensayo de ese

  2019-05-30

  

  La flor de Coleridge En el ensayo de ese nombre contenido en Otras inquisiciones leemos: De inmediato, y como corolario de estas ideas, nuestro ensayista da un salto para instalarnos en un mundo donde esta probabilidad se cumple: Como en el universo de Tlön, y siguiendo las premisas del idealis

• br Case report We report a case of

  2019-05-30

  

  Case report We report a case of an 18 year-old Caucasian male who was found to have thrombocytopenia at birth, with a platelet count of 58,000/mm3. Bone marrow biopsy was first performed in 1993, at 13 months of age, and showed 70–80% cellular marrow with occasional megakaryocytes and no evidence

• Dyslipidemia is characterized by increased total cholesterol

  2019-05-30

  

  Dyslipidemia is characterized by increased total cholesterol, LDL-C, and triglyceride levels, and decreased HDL-C levels. However, the association of ApoA1 polymorphism with serum HDL-C level remains controversial. The polymorphisms of ApoA1+84 TC, but not MspI, are associated with serum HDL-C. The

• br Methods br Results A

  2019-05-30

  

  Methods Results A total of 2136 cases, including 614 controls, and 707 LAA, 375 SVO, and 440 HICH cases, were enrolled in this study. Clinical parameters between the control individuals and patients with different stroke subtypes are listed in Table 1. The average age and serum HDL-C level wer

• Different ideas however emerged in the s and s

  2019-05-30

  

  Different ideas, however, emerged in the 1960s and 1970s in the minds of computational biologists interested in the theory of wave propagation in excitable media. Based on chemical [17] and numerical experiments, [18] scientists in the Soviet Union and the USA began to suggest that fibrillation was

• Introduction Ewing s sarcoma ES is a high grade neoplasm

  2019-05-30

  

  Introduction Ewing\'s sarcoma (ES) is a high-grade neoplasm representing the second most common primary bone malignancy in both children and adults. With a peak incidence at 15 years, this disease accounts for 2% of childhood cancers [1–3]. ES is defined as a bone tumor which may occur at any site

• A dual chamber ICD was

  2019-05-30

  

  A dual-chamber ICD was then implanted and the optimal atrioventricular (AV) interval to obtain the lowest PG was adjusted to a sensed PV interval of 70ms/AV pace of 60ms using echocardiography. After 1 week, the LVOT-PG had decreased to 68mmHg (Fig. 2B); by 3 weeks, it had decreased to 26mmHg (Fig.

• The congruence between BrS and ERS

  2019-05-30

  

  The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope

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