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br Materials and methods br Results
2024-04-28
Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi
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Pioneering studies on the immunomodulatory role
2024-04-28
Pioneering studies on the immunomodulatory role of adenosine date back to the early ‘70 s of last century (Fig. 1), when the critical role of this nucleoside in shaping the development and the activity of several immune cell populations was first established [[18], [19], [20], [21], [22]]. This the
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Further investigations were concerned to study the
2024-04-28
Further investigations were concerned to study the mechanisms by which GABA modulates adenosine-mediated effects in hippocampal tissue. From these results it can be concluded that endogenous GABA exerts an inhibitory effect through GABAA receptors via a predominant adenosine-mediated action and this
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For comprehensive understanding of actin myosin XI as a cont
2024-04-28
For comprehensive understanding of actin-myosin XI as a control network, it will be necessary to determine the functions of all the myosin XI and colorimetric assay isoforms. However, it is difficult to reveal the function of individual myosin XI isoforms because most myosin XI single knockouts exh
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br Thymic expression of AChR
2024-04-28
Thymic expression of AChR Both linear unfolded epitopes of AChR subunits and the intact AChR are avidly expressed in thymus, particularly by thymic epithelial cells and myoid cells [17], [18], [19]. AChR-antibody positive MG patients often show thymic hyperplasia, characterized by lymphoid follic
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The difficulty of characterizing nAChRs
2024-04-28
The difficulty of characterizing nAChRs in the central nervous system is also exemplified by early observations that nicotine caused no detectable effect when applied on a brain slice and it is only with the focal and high time resolution of more recent experiments that the effects of nicotinic neur
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To date more than different
2024-04-28
To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su
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W 54011 The diagnosis of ICP is
2024-04-28
The diagnosis of ICP is currently based on the presence of pruritus, raised fasting serum TBS levels above 10μmol/L, and/or elevated serum transaminases (in the absence of diseases that cause cholestasis or pruritus) as well as spontaneous relief of signs and symptoms within four to six weeks after
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Ryoichi et al modified potent clinical candidate VX with
2024-04-27
Ryoichi et al. modified potent clinical candidate VX-680 (6) with 3-cyano-6-(5-methyl-3-pyrazolamino)pyridine as Aurora kinase inhibitor. Substituted cyano pyridine derivative (7) inhibited proliferation of HCT-116 cells with an IC50 value of 115 nM. It showed tumor inhibition in mice model at a dos
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ATM is generally regarded to be the principal mediator
2024-04-27
ATM is generally regarded to be the principal mediator of the G1 apr 246 checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type of DNA dama
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Available data thus indicate that there are at least
2024-04-27
Available data thus indicate that there are at least two ways that HMGA proteins can induce localized changes in the chromatin structure of inducible gene promoters, both of which involve positioned nucleosomes that must be “remodeled” before gene transcription can occur. The first mechanism is exem
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Because of the critical roles played by
2024-04-27
Because of the critical roles played by AMPK in energy sensing and cancer cell survival, a huge number of drugs have been proposed to exert their pharmacological effects by means of AMPK activation (Kim and He, 2013). For example, metformin has been shown to activate AMPK in muscle (Sajan et al., 20
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Dose Response Studies Against Puromycin
2024-04-27
Dose–Response Studies Against Puromycin–Sensitive Aminopeptidase (PSA). PSA is a ubiquitous metallopeptidase encoded by the NPEPPS gene with subcellular distribution in the cytosol and nucleus [49]. Comprising of a 919 amino ascorbic acid receptor sequence, it has a broad substrate specificity, and
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MT SGL encourages a individual feature selection based
2024-04-27
MT-SGL encourages (a) individual feature selection based on the utility of the features across all tasks with ℓ2,1-norm and (b) task specific group selection based on the utility of the group with G2,1-norm, i.e., 5-fluorocytosine sale regions of interest (ROI) for that task. Unlike basic SGL for r
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Recently a Phase III study demonstrated that alectinib
2024-04-27
Recently, a Phase III study demonstrated that alectinib, the second-generation ALK inhibitor, might have a better response to ALK-rearrangement patients than crizotinib [10]. Should alectinib replace crizotinib as the frontline treatment for ALK-rearranged patients? Or should those patients be treat
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