• Previous studies from our laboratory

  2020-07-31

  

  Previous studies from our laboratory in CD1 mice using the incisional postoperative pain model have shown that the incision induces significant mechanical postoperative hyperalgesia lasting between 7 and 10days, with peak effect between 4h-2days (Cabañero et al., 2009a, Cabañero et al., 2009b, Campi

• DNA methylation is a relatively stable but reversible epigen

  2020-07-31

  

  DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla

• Our dietary reconstruction relies primarily

  2020-07-31

  

  Our dietary reconstruction relies primarily on collagen data. Considering the impact of local environment on the stable isotope ratios of foodwebs (Herrscher and Le Bras-Goude, 2010; Drucker and Henry-Gambier, 2005; Kinaston et al., 2014), specific attention was paid to characterize the stable carbo

• In our case series eyes with

  2020-07-31

  

  In our case series, eyes with retinal degeneration or normal fundus unexceptionally demonstrated structural and functional photoreceptor abnormalities corresponding to the funduscopic and/or perimetric lesions, even though the RPE layer was intact (Figure 5). By stark contrast to eyes with multiple

• Xenobiotic metabolism primarily occurs in liver which

  2020-07-31

  

  Xenobiotic metabolism primarily occurs in liver, which contains many enzymes to catalyze the transformation of xenobiotic. Usually, cytochrome P-450s (CYP450s) act as the first response for biotransformation of xenobiotic in organisms. CYP450s generally consist of various subfamily enzymes which can

• RING E ligases are often

  2020-07-31

  

  RING-E3 ligases are often found both as monomers and homodimers, but heterodimers have also been reported [11]. However, the dimerisation interfaces can vary, and are grouped in two distinct types, the RINGv-mediated interfaces and the non-RINGv mediated interfaces [13]. E3 ligases have also been sh

• br Materials and methods br Results br Discussion Because ev

  2020-07-31

  

  Materials and methods Results Discussion Because everolimus alleviates CMV infection in transplant recipients, we first tried to characterise the anti-CMV action without pretreatment, as other researchers have done (Kudchodkar et al., 2004, 2007; Moorman and Shenk, 2010). Although CMV repli

• T16Ainh - A01 The unique property of mutant

  2020-07-31

  

  The unique property of mutant IDH1/2 in producing an oncometabolite that has no known physiological function makes mutant IDH T16Ainh - A01 as obvious potential therapeutic targets for the treatment of IDH-mutated tumors (Rohle et al., 2013, Wang et al., 2013). Clinical studies have also suggested t

• According to the docking study results the difference

  2020-07-31

  

  According to the docking study results, the difference in biological activity of the tested compounds despite of their similar chemical structure could be explained. For the active molecules like 26, the presence of aromatic substituent with its conformational freedom seems to be crucial for the int

• Support for Cloninger s personality theory comes also from

  2020-07-30

  

  Support for Cloninger\'s personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD. In TWS119 to endocrine studies, which relate hormone levels mostly in the periphery (blood, saliva, urine) to

• Protection of DNA is a

  2020-07-30

  

  Protection of DNA is a cancer preventive mechanism; both oxidative and alkylating damage to colonocytes are known effects of dietary carcinogens. Concerning the DNA protection experiments, two different DNA damaging agents, an oxidant (H2O2) and alkylating (MMS) agent, were used. Hydrogen peroxide i

• br Testicular HSD B isoforms br HSD

  2020-07-30

  

  Testicular HSD3B isoforms HSD3B-inhibitory endocrine disruptors Many endocrine disruptors could be anti-androgens. One of their mechanisms is direct inhibition of testicular HSD3B activity [2,24]. These environmental endocrine disruptors are derived from food, environment and other consumer pr

• In reviewing the literature it is

  2020-07-30

  

  In reviewing the literature, it is apparent that three major methodological approaches are used to evaluate the behavioral effects induced by targeted Digoxin alterations. These methods include knockout procedures, antisense oligonucleotide strategies, and administration of specific CRF receptor an

• To extend these toxicity minimization strategies to D tissue

  2020-07-30

  

  To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account HATU in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially depende

• Paraffin embedded tissue blocks were transferred from the

  2020-07-30

  

  Paraffin embedded tissue blocks were transferred from the University of Florence, Florence, Italy, to the Department of Cellular Pathology at the Royal Free Hospital, London, UK, where the study was performed. Each tissue block was processed according to the reported CPA method and analysed for coll

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