• Experimental conditions may be critical

  2021-10-11

  

  Experimental conditions may be critical to explain one model or the other. The matter of Hippo-driven cytoplasmic sequestration (Varelas et al., 2008) of active SMAD complexes (Varelas et al., 2008) vs. TßR basolateral relocalization upon epithelial polarization (Nallet-Staub et al., 2015) as mechan

• 4-IPP br Concluding Remarks One of the

  2021-10-11

  

  Concluding Remarks One of the remarkable features of Hippo signaling is its sensitivity to the cytoskeleton and mechanical forces. Progress has been made recently in identifying molecular mechanisms by which the cytoskeleton can influence Hippo signaling, but among the many outstanding questions

• br Conclusion br Funding br Availability of data and materia

  2021-10-11

  

  Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop

• TH588 mg Introduction Hepatocellular carcinoma HCC is the fi

  2021-10-11

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, TH588 mg virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]]. In China, mor

• br Amino acids The role

  2021-10-11

  

  Amino acids: The role of leucine Amino so much metabolism plays a central role in brain physiology, as several amino acids serve as biosynthetic precursors for neurotransmitter synthesis [36]. In addition, the amino acids L-leucine and L-lysine may participate in ketogenesis. For these reasons,

• Selection of the month br Fibrosis

  2021-10-11

  

  Selection of the month Fibrosis Liver protection device Non-alcoholic steatohepatitis Genetic metabolic liver disease Hepatitis C virus (HCV) infection Hepatitis B virus (HBV) infection Cirrhosis Regeneration Introduction Upon catalysis by hepatic and bacterial enzymes, c

• Rapid action of E on GnRH neurons has been

  2021-10-11

  

  Rapid action of E2 on GnRH neurons has been known for some time. E2 hyperpolarizes guinea pig GnRH neurons, alters cAMP production in GT1-cells and stimulates or inhibits [Ca2+]i oscillations within 15 min (Lagrange et al., 1995; Navarro et al., 2003; Temple et al., 2004; Romanò et al., 2008). Impor

• br Acknowledgments This work was

  2021-10-11

  

  Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 81703451) and the China Postdoctoral Science Foundation Grant (No. 2017M611269). Introduction According to the International League Against Epilepsy (ILAE), epilepsy is generally defin

• AZD0156 br Ghrelin interactions with the opioid

  2021-10-11

  

  Ghrelin interactions with the opioid system The endogenous opioid system is an important regulator of appetite and metabolism (Bodnar, 2017, Nogueiras et al., 2012). In fact, several pharmacological studies have demonstrated that agonists of the three opioid receptors (mu, kappa, and delta) incre

• Both anxiety like behavior and sucrose preference intake wer

  2021-10-09

  

  Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo

• br Methods br Results br Discussion Exercise results in

  2021-10-09

  

  Methods Results Discussion Exercise results in a remarkable redistribution of blood flow, which increases in active skeletal muscles but decreases in the splanchnic circulation. The regional blood flow in the kidney, spleen, stomach and intestine was measured by using the microsphere techn

• Increasing number of experimental data reveal that both ROS

  2021-10-09

  

  Increasing number of experimental data reveal that both ROS and RNS are multifunctional molecules playing a substantial role in plant physiology and particularly in seed biology (Bailly et al., 2008; Šírová et al., 2011; Yu et al., 2014). Dual function of RNS can be described by the model of “nitros

• br GSNOR regulates SA synthesis and SA signalling The

  2021-10-09

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic BMS-626529 (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistanc

• br Introduction Atherothrombosis is associated with the pres

  2021-10-09

  

  Introduction Atherothrombosis is associated with the presence of a low-grade, subclinical smoldering inflammatory response [1]. Several inflammatory markers, among them high-sensitive C-reactive protein (hs-CRP) [2], the erythrocyte sedimentation rate (ESR) [3], fibrinogen concentrations [4], int

• Introduction l Glutamate is a major excitatory neurotransmit

  2021-10-09

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

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